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KMID : 0379519990150030395
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한국독성학회지
1999 Volume.15 No. 3 p.395 ~ p.403
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Local Irritation Study of Recombinant Human Basic Fibroblast Growth Factor in Rabbits
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Cho Hyoen
Kim Dong-Hwan
Kang Kyung-Koo
Ahn Byoung-Ok
Park Beom-Soo
Kang Soo-Hyung
Kim Won-Bae
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Abstract
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Primary and cumulative irritation of recombinant human basic fibroblast growth factor (bFGF) on the skin, primary irritation on ocular mucous membrane and cumulative local toxicity by subcutaneous injection were investigated using albino rabbits. The concentration of bFGF in liquid formulation was 0.01%, which is expected to be used for clinical practice. In primary and repeated dermal irritation studies, 0.01% bFGF solution did not induce any local response at the applied sites. Instillation of 0.01% bFGF solution to conjunctival sac also resulted in none of local changes of the conjuntivae and eyes throughout the observation period. Repeated subcutaneous injection of bFGF, however, induced edema, celluar infiltration, proliferation of fibroblasts, neovascularization and fibrotic changes confined to the injection site. These changes were thought to be attributable to its pharmacological effects. The present study demonstrates that 0.01% bFGF solution has no irritating potential when applied to intact skin.
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KEYWORD
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Basic fibroblast growth factor, bFGF, Local irritation, Rabbit
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